
<h2>TL;DR</h2>
<p>Both are ad mediation techniques: requests are sent to several demand partners simultaneously.</p>
<p>Differences:</p>
<ul>
  <li>Header Bidding or Pre-bidding: NOT created by Google. A publisher runs an auction on its webpage/app before sending an ad request to Google Ad Manager. Client side (publishers place HTML or JavaScript code in the header of their site to run a real time pre-assessment).</li>
  <li>Open Bidding: owned by Google, as an reaction to Header Bidding. Server-side (the auction will be happening inside GAM), unified auction; 3rd party ad exchanges compete with Google's AdX</li>
</ul>
<h2>Header Bidding</h2>
<p>A programmatic advertising technique in which publishers bid on multiple advertising exchanges in real time. Publishers make 3rd party exchange compete with Google Ad Manager</p>
<ul>
  <li>AdX - GAM - header bidding</li>
  <li>Exchange - header bidding</li>
</ul>
<h2>Open Bidding</h2>
<p>Google’s “auction of auctions”</p>
<ul>
  <li>AdX - OB - GAM</li>
  <li>AdX - OB - AdMob</li>
  <li>AdX - Exchange - GAM</li>
  <li>AdX - Exchange - AdMob</li>
</ul>


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